Prostaglandin D2 Connected to Hair Loss

Prostaglandin D2 is discovered to be an inhibitor of hair growth in androgenetic alopecia. This is according to a study posted in the March 21 issue of Science Translational Medicine. The study was made by a group of researchers led by Luis Garza from the University Of Pennsylvania School Of Medicine in Philadelphia.

The researchers investigated the mechanisms for decreased hair growth in androgenetic alopecia. A global gene expression approach was used to determine different genes that are found in balding and non-balding scalp sections from the same person.

The researchers found out that when they compared hair scalps of men with AGA, prostaglandin D2 synthase was found to have increased levels in messenger RNA and protein levels in bald scalp. PGD2 was also found to have increased levels in the same area.

When studying mice during normal follicle cycle, there was an increase in PGD2 and PTGDS levels right after the regression phase. Explanted human hair follicles in mice showed PGD2 to inhibit hair growth. The PGD2 receptor G protein-coupled receptor 44 was needed for hair growth inhibition.

The results showed that PGD2 is an inhibitor of hair growth in cases of androgenetic alopecia. IT suggested that PGD2-GPR44 as a potential target for hair loss treatments.

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